The Post-Acute and Long-Term Care (PALTC) is arguably the most at need population, but most challenging implementation setting, for deprescribing. In early 2020, the Society for Post-Acute and Long-Term Care Society (formerly AMDA) sponsored Drive to Deprescribe (D2D) initiative was developed to address the unique deprescribing-related needs of PA-LTC residents and providers alike. This session is designed to: 1. Describe the deprescribing conundrum in the PA-LTC setting; 2. Present the D2D initiative; and 3. Discuss interim aggregate data and lessons learned from the D2D initiative.